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Case Study

The Case Study 1:  The Stereoselective Synthesis of AMG-076
The Case Study 2:  The Synthesis of HCV Protease Inhibitor
The Case Study 3:  The Synthesis of Immunosuppressive Agent FTY-720

The Case Study 1:

The Stereoselective Synthesis of AMG-076
(Ref: Denise Andersen et al., J. Org. Chem., 2007, 72, 9648-9655.)

 

The 650 mg of AMG-076 had been synthesized starting from a 15 g of compound 1 by 14 synthetic steps in 5 weeks.

The Case Study 2:

The Synthesis of HCV Protease Inhibitor
(Ref: Anja Johansson et al., Bioorg. Med. Chem., 2006, 16, 544.

The 115 mg of HCV protease inhibitor had been synthesized by 13 steps in 5 weeks.

The Case Study 3:

The Synthesis of Immunosuppressive Agent FTY-720
(Ref: Alois Furstner et al., J. Org. Chem., 2004, 69, 3950-3952.)

The 2 g of FTY-720 had been synthesized by 9 steps in 4 weeks.

 

 

 

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